2014年11月20日公開iPS細胞関連特許
2014/11/23
Pub. No.: WO/2014/186766 International Application No.: PCT/US2014/038491
Publication Date: 20.11.2014 International Filing Date: 16.05.2014
IPC:C12N 5/071 (2010.01), C12N 15/63 (2006.01)
Applicants: THE BROAD INSTITUTE, INC. [US/US]; 7 Cambridge Center Cambridge, MA 02142 (US).
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138 (US)
Inventors: MIKKELSEN, Tarjei; (US).
CACCHIARELLI, Davide; (US)
Agent: RONES, Melissa, S.; Ropes & Gray LLP Prudential Tower 800 Boylston Street Boston, MA 02199 (US)
Priority Data:
61/824,918 17.05.2013 US
Title (EN) REPROGRAMMED CELLS AND METHODS OF PRODUCTION AND USE THEREOF
Abstract:
(EN)The present invention relates generally to a secondary reprogramming technique and its uses. More particularly, it concerns immortalized secondary somatic cells, secondary induced pluripotent stem cells (iPSCs), secondary induced multipotent progenitor cells (iMPCs) and tertiary somatic cells derived therefrom, and methods of using these cells to assess the effects of agents on cells and for medical treatment of subjects.
Publication Date: 20.11.2014 International Filing Date: 16.05.2014
IPC:C12N 5/071 (2010.01), C12N 15/63 (2006.01)
Applicants: THE BROAD INSTITUTE, INC. [US/US]; 7 Cambridge Center Cambridge, MA 02142 (US).
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138 (US)
Inventors: MIKKELSEN, Tarjei; (US).
CACCHIARELLI, Davide; (US)
Agent: RONES, Melissa, S.; Ropes & Gray LLP Prudential Tower 800 Boylston Street Boston, MA 02199 (US)
Priority Data:
61/824,918 17.05.2013 US
Title (EN) REPROGRAMMED CELLS AND METHODS OF PRODUCTION AND USE THEREOF
Abstract:
(EN)The present invention relates generally to a secondary reprogramming technique and its uses. More particularly, it concerns immortalized secondary somatic cells, secondary induced pluripotent stem cells (iPSCs), secondary induced multipotent progenitor cells (iMPCs) and tertiary somatic cells derived therefrom, and methods of using these cells to assess the effects of agents on cells and for medical treatment of subjects.
